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Peripheral Neuropathy

  • Definition

    Peripheral neuropathy is damage to the peripheral nerves. These are the nerves that connect your spinal cord to the rest of your body.
    Peripheral Nerves of the Foot
    Nucleus factsheet image
    Copyright © Nucleus Medical Media, Inc.
  • Causes

    Many health conditions can cause peripheral neuropathy. The damage may occur due to:
    • Trauma from nerve compression or inflammation
    • Certain medications, such as chemotherapy treatments for cancer
    • Vitamin deficiencies
    • Hereditary syndromes
    • Exposure to toxins and heavy metals, such as lead , mercury , or pesticides
    • Exposure to cold or radiation
    • Prolonged treatment in the intensive care unit
    Health conditions that can damage peripheral nerves include:
  • Risk Factors

    Having certain health conditions may increase your chance of getting peripheral neuropathy.
  • Symptoms

    Damage to the peripheral nerves often results in sensory and motor symptoms in the:
    • Arms
    • Legs
    • Hands
    • Feet
    Other parts of the body can also be affected. Symptoms depend on which nerves are involved. They can range from mild to severe and may seem worse at night. Sensations and pain may occur in the upper or lower limbs and move toward the trunk, such as from the feet to the calves.
    Peripheral neuropathy may cause:
    • Numbness or reduced sensation
    • Tingling
    • Pain, often a burning or sharp, cutting sensation
    • Sensitivity to touch
    • Muscle twitches
    • Muscle weakness
    • Difficulty with walking
    • Loss of coordination or balance
    • Paralysis
    If untreated, peripheral neuropathy can lead to:
    • Loss of reflexes and muscle control
    • Muscle atrophy—loss of muscle bulk
    • Foot deformities
    • Injuries to the feet that go unnoticed and become infected
    If you have motor or sensory neuropathy, you may also have autonomic neuropathy. This is associated with symptoms such as:
    • Problems regulating blood pressure
    • Constipation
    • Erectile dysfunction
    • Difficulty breathing
  • Diagnosis

    The doctor will ask about your symptoms and medical history. A physical exam will be done. It may include examining:
    • Muscle strength
    • Reflexes
    • Balance
    • Coordination
    • Ability to feel vibration, temperature, and light touch
    • Sensation in the feet using a fine flexible wire—Semmes-Weinstein monofilaments test
    Additional tests may also include:
    • Tests of your bodily fluids and tissues:
      • Blood tests, such as glucose, vitamin B12 level, and thyroid function tests
      • Serum/urine electrophoresis
      • Genetic testing
      • Lumbar puncture
      • Nerve fiber density skin biopsy
      • Nerve or muscle biopsy
    • Evaluation of your nerves and muscles:
    • Imaging tests to evaluate nerves and other structures:
    • Your doctor may need to evaluate other family members for this condition.
  • Treatment

    Talk with your doctor about the best treatment plan for you. Options may include:
    Treatment for the Underlying Illness or Exposure
    Treating the underlying illness can decrease symptoms or make them go away. For instance, if it is caused by diabetes, controlling blood sugar levels may help. In some cases, neuropathy caused by medications or toxins is completely reversed when these substances are stopped or avoided. Correction of vitamin B12 deficiency often improves symptoms.
    Physical Therapy
    Certain exercises may help stretch shortened or contracted muscles and increase joint flexibility. In long-standing cases, splinting the joint may be required to protect and rest it, while maintaining proper alignment.
    Orthotics, such as supports and braces, may help with:
    • Deformities
    • Balance issues
    • Muscle weakness
    Maintaining physical activity is also important.
    Prescription and over-the-counter pain medications are often used to ease discomfort.
    Medications used to treat depression and prevent convulsions can relieve neuropathy symptoms.
    For severe and potentially life-threatening cases, such as Guillain-Barre syndrome , treatment includes:
    Other Therapies
    These therapies are aimed at reducing symptoms:
    Surgery can relieve the pressure on nerves. For example, surgeons commonly release fibrous bands in the wrist to treat carpal tunnel syndrome .
  • Prevention

    To help reduce your chance of peripheral neuropathy:
    • Manage chronic medical conditions with the help of your doctor. If you have diabetes, make sure you have regular foot exams.
    • Eat a healthful diet that is low in saturated fat and rich in whole grains, fruits, and vegetables.
    • Limit your alcohol intake to a moderate level. This means 2 or fewer drinks per day for men and 1 or fewer for women.
    • Avoid toxic chemicals.

    American Chronic Pain Association

    The Neuropathy Association


    Canadian Diabetes Association

    Health Canada


    Baron R, Binder A, et al. Neuropathic pain: diagnosis, pathophysiological mechanisms, and treatment. Lancet Neurol. 2010;9(8):807-819.

    Diabetic neuropathies: The nerve damage of diabetes. National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health website. Available at: Updated November 26, 2013. Accessed May 30, 2014.

    Karlsson P, et al. Epidermal nerve fiber length density estimation using global spatial sampling in healthy subjects and neuropathy patients. J Neuropathol Exp Neurol. 2013 Mar;72(3):186-93.

    Peripheral neuropathy. EBSCO DynaMed website. Available at: Available at: Updated April 15, 2014. Accessed May 30, 2014.

    12/20/2007 DynaMed's Systematic Literature Surveillance 2007 safety alerts for drugs, biologics, medical devices, and dietary supplements: Carbamazepine (marketed as Carbatrol, Equetro, Tegretol and generics). Medwatch. US Food and Drug Administration website. Available at:

    10/5/2009 DynaMed's Systematic Literature Surveillance Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination as a screening tool for diabetic peripheral neuropathy. J Vasc Surg. 2009;50:675-682,682.

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