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Interstitial Cystitis

(IC; Painful Bladder Syndrome)
  • Definition

    Interstitial cystitis is chronic inflammation of the wall of the bladder. Inflammation can cause scarring and/or pinpoint bleeding of the bladder wall. It can also lead to decreased space to hold urine.
    The Bladder
    The bladder
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  • Causes

    Although the symptoms are similar to those of a bladder infection, there is usually no clear cause. Bacteria, fungi, and/or viruses are rarely found in the urine of people with interstitial cystitis. Possible causes include:
    • An autoimmune response that occurs following a bacterial infection of the bladder
    • A leaky inner lining of the bladder that allows irritating substances in the urine to come into contact with the bladder wall
  • Risk Factors

    Interstitial cystitis is more common in women and Caucasians.
    Factors that may increase your chance of interstitial cystitis include:
  • Symptoms

    The symptoms of interstitial cystitis vary from person to person. They can also occur in cycles. Symptoms may include:
    • Urgent need to urinate.
    • Frequent need to urinate several times a day.
    • Discomfort, pain, or pressure in the bladder or pelvic area when the bladder is full, and relief when the bladder is emptied
    • Pain during and after intercourse or during orgasms
    • Blood in the urine
    • Depression
    • Pain in the vulva or vagina in women, or in the testes, groin, or tip of penis in men
  • Diagnosis

    You will be asked about your symptoms and medical history. A physical exam will be done.
    Your bodily fluids may be tested. This can be done with:
    • Urine test
    • Urine culture
  • Treatment

    There is no known treatment to cure interstitial cystitis. Treatment is aimed at managing symptoms. You may have to try several different treatments before you improve.
    Treatment may include one or more of the following:
    Bladder Distention
    Some people experience relief after a bladder distention, which is done during a cystoscopy.
    Bladder Instillation
    During bladder instillation, a solution is put into the bladder through a tube in the urethra. It is held for anywhere from a few seconds to 15 minutes, and then voided. There are several different types of solutions used. Some solutions coat the bladder, some solutions are anesthetics, and some solutions are thought to decrease the inflammation.
    Mediations may include:
    • Over-the-counter pain relievers
    • Prescription pain relievers
    • Antidepressants
    • Antihistamines
    • Botulinum toxin A injections
    There is no research linking diet to interstitial cystitis. However, many people find that changes in diet can help relieve pain. Different people have different foods that act as triggers. Foods commonly reported to aggravate interstitial cystitis include:
    • Coffee
    • Chocolate
    • Artificial sweeteners
    • Alcohol
    • Acidic foods
    • Carbonated beverages
    Transcutaneous Electrical Nerve Stimulation (TENS)
    TENS uses an external device that sends mild electrical impulses into the body. It has helped relieve pain and decrease the frequency of urination in some people.
    InterStim Therapy
    InterStim therapy uses an approved device. It has been reported to possibly provide relief in some people with interstitial cystitis who do not respond to other treatments. The electronic device is implanted into the sacral nerve roots of the spinal cord. Electrical impulses are sent to these roots in regular intervals. The impulses are sent to adjust the neural output of the pelvic nerves supplying the bladder.
    While some have reported some relief, they appear to be in the minority. Doctors do not know yet what makes the device helpful.
    Bladder Training
    Some people are able to train their bladder to have better control by setting a regular, timed schedule for emptying their bladder. The amount of time between voids is gradually increased. Bladder training should be attempted only after pain relief has been accomplished.
    Surgery is used after all other treatment methods have been exhausted and the pain remains severe. Surgical options include:
    • Ulcer fulguration—instruments inserted through the urethra are used to burn ulcers with electricity or laser
    • Ulcer removal—instruments inserted through the urethra are used to cut out ulcers
    • Bladder augmentation—a segment of bowel is used to increase the capacity of the bladder
    • Cystectomy—removal of the entire bladder
    Surgery is rarely done for this condition. Many people continue to have pain even after surgery.
  • Prevention

    There are no current guidelines for preventing interstitial cystitis because the cause is unknown.

    Interstitial Cystitis Association

    Interstitial Cystitis Network


    Health Canada

    Women's Health Matters


    Interstitial cystitis. American Urological Association Foundation. Available at: Accessed March 7, 2016.

    Interstitial cystitis—Painful bladder syndrome. EBSCO DynaMed website. Available at: Updated November 23, 2015. Accessed March 7, 2016.

    Interstitial Cystitis/Painful Bladder Syndrome. National Institute of Diabetes and Digestive and Kidney Diseases website. Available at: Updated September 2013. Accessed March 7, 2016.

    Offiah I, McMahon SB, O'Reilly BA. Interstitial cystitis/bladder pain syndrome: Diagnosis and management. Int Urogynecol J. 2013;24(8):1243-1256.

    8/18/2014 DynaMed's Systematic Literature Surveillance Pinto R, Lopes T, et al. Ulcerative and nonulcerative forms of bladder pain syndrome/interstitial cystitis do not differ in symptom intensity or response to onabotulinum toxin A. Urology. 2014;83(5):1030-1034.

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