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Xanthelasma and Xanthoma

  • Definition

    Xanthoma is a condition in which fatty deposits form beneath the skin. They range from very small to up to 3 inches in size. Xanthomas are not painful or dangerous, but can be cosmetically disfiguring. Xanthomas may appear anywhere on the body, but are most frequently found on the elbows, joints, tendons, knees, hands, feet, and buttocks.
    Xanthelasma is a form of xanthoma that appears on the eyelids.
  • Causes

    Xanthoma is typically caused by:
    • Elevated levels of fats in the blood
    • Metabolic disorders including:
    Although xanthelasma may be associated with high triglyceride and cholesterol levels, it can occur without cholesterol problems.
  • Risk Factors

    Factors that may increase your chance of xanthoma include:
    • Having a metabolic disorder listed above
    • Having extremely high cholesterol and/or triglyceride levels
    • Increased age
  • Symptoms

    Xanthoma may cause:
    • Bumps under the skin
    • Skin lesions that are:
      • Many different shapes
      • Yellow to orange
      • Have well-defined borders
    Xanthomas may be tender, itchy, and painful.
  • Diagnosis

    Xanthoma is usually diagnosed by examining the skin growths. A biopsy of the tissue will confirm a fatty deposit.
    Skin Biopsy
    Skin proceedure
    Copyright © Nucleus Medical Media, Inc.
    A blood lipid profile and other tests may be done to determine the underlying condition responsible for the appearance of xanthomas.
  • Treatment

    Treating xanthoma consists of treating and controlling the underlying health conditions that cause the fatty deposits to develop. Better control of the metabolic disorders that can lead to xanthoma can reduce their occurrence.
    Xanthomas that are removed can return after treatment.
    Other treatment options for xanthomas include:
    Surgery
    Surgery may be used to remove the fatty deposits.
    Laser
    Laser surgery with CO2 laser, pulse-dye laser, or Erbium-YAG laser can be performed.
    Chemical
    Treatment with trichloroacetic acid may also be used to treat xanthomas.
  • Prevention

    To help reduce your chances of xanthoma:
    • Keep blood lipids and cholesterol at a healthy level
    • Keep metabolic disorders well-controlled
  • RESOURCES

    American Academy of Dermatology http://www.aad.org

    Family Doctor—American Academy of Family Physicians http://familydoctor.org

    CANADIAN RESOURCES

    HealthLinkBC http://www.healthlinkbc.ca

    Canadian Dermatology Association http://www.dermatology.ca

    References

    Feingold K, Castro G, et al. Cutaneous xanthoma in association with paraproteinemia in the absence of hyperlipidemia. J Clin Invest. 1989 Mar;83(3):796-802.

    Xanthoma. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated September 22, 2011. Accessed August 27, 2014.

    Xanthomas. DermNet NZ website. Available at: http://www.dermnetnz.org/dermal-infiltrative/xanthoma.html. Updated May 18, 2014. Accessed August 27, 2014.

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