Theophylline

  • Trade Names :

    • Accurbron
    • Aerolate
    • Aquaphyllin
    • Asmalix
    • Elixomin
    • Elixophyllin
    • Lanophyllin
    • Quibron-T
    • Quibron-T-SR
    • Slo-bid
    • Slo-Phyllin
    • T-Phyl
    • Theo-24
    • Theo-Dur
    • Theo-Sav
    • Theo-X
    • Theobid
    • Theochron
    • Theoclear L.A.
    • Theoclear-80
    • Theolair
    • Theolair-SR
    • Theospan-SR
    • Theostat 80
    • Theovent
    • Uni-Dur
    • Uniphyl
  • Once among the most common treatments for asthma, theophylline is no longer widely used, having been replaced by drugs that cause fewer side effects.
     
  • Vitamin B6
    Theophylline appears to impair the normal conversion of vitamin B 6 into the more active substance pyridoxal 5'-phosphate (PLP). 1–4 These findings have led some researchers to suspect that some of the many side effects of theophylline could be caused, at least in part, by interference with B 6 activity. Indeed, one study found that B 6 supplements might help reduce theophylline-induced tremors. 5
  • St. John's Wort
    Evidence suggests the herb St. John's wort can lower blood levels of theophylline, making it less effective. 6,7
  • Cayenne
    Oral cayenne might increase the absorption of theophylline, 8 which could lead to an increased risk of theophylline toxicity.
  • Ipriflavone
    Like cayenne, the supplement ipriflavone may increase levels of theophylline in the body, possibly increasing the risk of toxicity. 9
  • References

    1 Shimizu T, Maeda S, Mochizuki H, et al. Theophylline attenuates circulating vitamin B 6 levels in children with asthma. Pharmacology 49: 392–397, 1994.

    2 Martinez de Haas MG, Poels PJ, de Weert CJ, et al. Subnormal vitamin B 6 levels in theophylline users. Ned Tijdschr Geneeskd 141: 2176–2179, 1997.

    3 Ubbink JB, Delport R, Bissbort S, et al. Relationship between vitamin B 6 status and elevated pyridoxal kinase levels induced by theophylline therapy in humans. J Nutr 120: 1352–1359, 1990.

    4 Delport R, Ubbink JB, Vermaak WJ, and Becker PJ. Theophylline increases pyridoxal kinase activity independently from vitamin B 6 nutritional status. Res CommunChem Pathol Pharmacol 79: 325–333, 1993.

    5 Bartel PR, Ubbink JB, Delport R, et al. Vitamin B 6 supplementation and theophylline-related effects in humans. Am J Clin Nutr 60: 93–99, 1994.

    6 Nebel A, Baker RK, and Kroll DJ. Potential metabolic interaction between theophylline and St. John's wort. Ann Pharmacother 33(4): 502, 1999.

    7 Jobst KA, McIntyre M, St. George D, et al. Safety of St. John's wort (Hypericum perforatum).Lancet 355(9203): 575, 2000.

    8 Bouraoui A, Toumi A, Mustapha HB, et al. Effects of capsicum fruit on theophylline absorption and bioavailability in rabbits. Drug Nutr Interact 5: 345–350, 1998.

    9 Monostory K and Vereczkey L. The effect of ipriflavone and its main metabolites on theophylline biotransformation. Eur J Drug Metab Pharmacokinet 21(1): 61–66, 1996.

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