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Hypoparathyroidism

(Underactive Parathyroid)
  • Definition

    The parathyroid glands are four pea-sized glands. They are located next to the thyroid gland in the neck. The glands secrete the parathyroid hormone (PTH). PTH helps to regulate the level of calcium in the blood.
    In hypoparathyroidism, there is not enough PTH secreted. This causes low levels of calcium in the blood. Low blood calcium is known as hypocalcemia.
    Thyroid and Parathyroid Glands: Posterior (Back) View
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    Copyright © Nucleus Medical Media, Inc.
  • Causes

    Hypoparathyroidism may be caused by:
    • Removal of the parathyroid glands
    • Underlying autoimmune disorders
    • Absence of the parathyroid glands at birth
    • Damage to the parathyroid glands
    • Genetics conditions such as DiGeorge syndrome
    • Magnesium deficiency due to alcoholism and/or malnutrition
    • Other causes, such as metal overload from iron, magnesium, or aluminium
    In some cases, a cause cannot be found.
  • Risk Factors

    Factors that increase your chances of hypoparathyroidism include:
    • Multiple autoimmune disorders
    • Thyroid or parathyroid surgery
    • Family history of hypoparathyroidism
  • Symptoms

    Hypoparathyroidism does not always cause symptoms. If symptoms do develop, they may include:
    • Weakness
    • Muscle cramps or twitching
    • Pain
    • Difficulty with walking
    • Tingling around the mouth, fingers, and toes
    • Excessive nervousness
    • Loss of memory
    • Mood swings
    • Anxiety
    • Blurred vision due to cataracts
    • Thin, brittle nails
    • Dry and scaly skin
    • Seizures
  • Diagnosis

    You will be asked about your symptoms and medical history. A physical exam will be done.
    Your bodily fluids may be tested. This can be done with:
    • Blood tests
    • Urine test
    Images may be taken of your bodily structures. This can be done with:
  • Treatment

    Talk with your doctor about the best plan for you. Treatment options include the following:
    Calcium and Vitamin D Supplementation
    Calcium and vitamin D will usually be taken indefinitely. They are often taken by mouth.
    Calcium may be given by injection. This is done when immediate symptom relief is needed.
  • Prevention

    There are no current guidelines to prevent hypoparathyroidism.
  • RESOURCES

    Hypoparathyroidism Association, Inc. http://www.hypoparathyroidism.org

    National Organization for Rare Disorders http://www.rarediseases.org

    CANADIAN RESOURCES

    Canadian Society of Endocrinology & Metabolism http://www.endo-metab.ca

    Health Canada http://www.hc-sc.gc.ca

    References

    Definition of hypoparathyroidism and related disorders. The Hypoparathyroidism Association website. Available at: https://www.hypopara.org/about-hpth/definition.html. Accessed September 30, 2014.

    Hypoparathyroidism. EBSCO DynaMed website. Available at: http://www.ebscohost.com/dynamed. Updated June 2, 2014. Accessed September 30, 2014.

    Hypoparathyroidism. National Organization for Rare Disorders website. Available at: http://www.rarediseases.org/rare-disease-information/rare-diseases/byID/703/viewFullReport. Updated April 2, 2014. Accessed September 30, 2014.

    Marx SJ. Hyperparathyroid and hypoparathyroid disorders. N Engl J Med. 2000;343:1863.

    Moffett JM, Suliburk J. Parathyroid autotransplantation. Endocr Pract. 2011 Mar-Apr;17 Suppl 1:83-89.

    Testini M, Gurrado A, et al. Hypoparathyroidism after total thyroidectomy. Minerva Chir. 2007 Oct;62(5):409-415.

    Thakker RV. Genetic developments in hypoparathyroidism. Lancet. 2001;357:974.

    Winer KK, Ko CW, et al. Long-term treatment of hypoparathyroidism: a randomized controlled study comparing parathyroid hormone (1-34) versus calcitriol and calcium. J Clin Endocrinol Metab. 2003;88:4214-4220.

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